TARGET COMPOUND DESC P08908 CHEMBL299097 Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand P08908 CHEMBL64727 Binding affinity for 5-hydroxytryptamine 1A receptor P08908 CHEMBL159483 Affinity of compound towards 5-hydroxytryptamine 1A receptor was evaluated using radioligand binding technique P08908 CHEMBL146751 Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay P08908 CHEMBL64610 Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]OH-DPAT P08908 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P08908 CHEMBL363328 Inhibitory activity against 5-hydroxytryptamine receptor 1A using (+/-)-[3H]-8-hydroxydipropylaminotetralin P08908 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P08908 CHEMBL66310 Binding affinity for 5-hydroxytryptamine 1A receptor P08908 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P08908 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P28222 CHEMBL350637 Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor P28222 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P28222 CHEMBL63799 Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells P28222 CHEMBL114303 Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro P28222 CHEMBL116161 Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro P28222 CHEMBL114877 Ability to displace [3H]5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro P28222 CHEMBL294547 Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells P28222 CHEMBL370110 Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR P28222 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P28222 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P28222 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P28221 CHEMBL143951 Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells P28221 CHEMBL159483 Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells P28221 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P28221 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P28221 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P28221 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P28221 CHEMBL117249 Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells P28221 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 1D receptor P28221 CHEMBL148071 Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement. P28221 CHEMBL88784 Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra P28221 CHEMBL90405 Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra P28566 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P28566 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P28566 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P28566 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P28566 CHEMBL22744 Binding affinity to 5HT1E receptor P28566 CHEMBL15228 Inhibition of U-46,619 + phentolamine by the compound in response of SEC P28566 CHEMBL22744 Inhibitory activity against 5-hydroxytryptamine 1E receptor subtype P28566 CHEMBL15228 Inhibition of Arachidonic acid by the compound in response of SEC P28566 CHEMBL335423 Ability to inhibit the binding of [3H]5-HT to 5-hydroxytryptamine receptor P28566 CHEMBL334923 Compound was tested for binding affinity against 5-HT1 receptor P28566 CHEMBL14651 Stimulatory activity against serotonin secretion (SEC). P30939 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P30939 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P30939 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P30939 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P30939 CHEMBL15228 Inhibition of U-46,619 + phentolamine by the compound in response of SEC P30939 CHEMBL15228 Inhibition of Arachidonic acid by the compound in response of SEC P30939 CHEMBL335423 Ability to inhibit the binding of [3H]5-HT to 5-hydroxytryptamine receptor P30939 CHEMBL334923 Compound was tested for binding affinity against 5-HT1 receptor P30939 CHEMBL14651 Stimulatory activity against serotonin secretion (SEC). P30939 CHEMBL14837 Stimulatory activity against serotonin secretion (SEC). P30939 CHEMBL14982 Stimulatory activity against serotonin secretion (SEC). P28223 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P28223 CHEMBL1214045 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL1214176 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL1214304 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL1214305 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL1214366 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL1214545 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL1213933 Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells P28223 CHEMBL569475 Agonist activity at 5HT2A receptor expressed in HEK cells assessed as inhibition of serotonin-induced inositol phosphate accumulation P28223 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P28223 CHEMBL436513 Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cells P41595 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P41595 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P41595 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P41595 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P41595 CHEMBL384160 Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release P41595 CHEMBL472416 Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay P41595 CHEMBL21343 Inhibition of 5HT2B receptor P41595 CHEMBL493 Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) P41595 CHEMBL1909072 Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) P41595 CHEMBL214554 Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release P41595 CHEMBL6616 Displacement of radiolabeled DOI from human 5HT2B receptor agonist site P28335 CHEMBL54720 Binding affinity towards 5-hydroxytryptamine 2C receptor P28335 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P28335 CHEMBL53485 Binding activity against 5-hydroxytryptamine 2C receptor from pig cortex membrane using [3H]mesulergine as radioligand. P28335 CHEMBL300209 Binding activity against 5-hydroxytryptamine 2C receptor from pig cortex membrane using [3H]mesulergine as radioligand. P28335 CHEMBL493625 Displacement of [3H]mesulergine from human recombinant 5HT2C receptor expressed in CHOK1 cell membrane P28335 CHEMBL600012 Displacement of [3H]mesulergine from human recombinant 5HT2C receptor expressed in CHO-K1 cells P28335 CHEMBL604952 Displacement of [3H]mesulergine from human recombinant 5HT2C receptor expressed in CHO-K1 cells P28335 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P28335 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P28335 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P28335 CHEMBL65413 Binding affinity towards 5-hydroxytryptamine 2C receptor P46098 CHEMBL54720 Displacement of [3H]granisetron form 5HT3 receptor in hybrid NG180-15 cells P46098 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor P46098 CHEMBL143489 Binding affinity towards 5-hydroxytryptamine 3 receptor P46098 CHEMBL54125 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand P46098 CHEMBL1278087 Displacement of [3H]BRL-43694 from human 5HT3 receptor expressed in HEK293 cells by liquid scintillation counting P46098 CHEMBL342833 Binding affinity towards 5-hydroxytryptamine 3 receptor P46098 CHEMBL140856 Binding affinity towards 5-hydroxytryptamine 3 receptor P46098 CHEMBL314107 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor P46098 CHEMBL244561 Antagonist activity at human 5HT3A receptor expressed in HEK293 cells by FMP assay P46098 CHEMBL300725 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand P46098 CHEMBL388212 Antagonist activity at human 5HT3A receptor expressed in HEK293 cells by FMP assay O95264 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor O95264 CHEMBL143489 Binding affinity towards 5-hydroxytryptamine 3 receptor O95264 CHEMBL54125 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand O95264 CHEMBL342833 Binding affinity towards 5-hydroxytryptamine 3 receptor O95264 CHEMBL140856 Binding affinity towards 5-hydroxytryptamine 3 receptor O95264 CHEMBL314107 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor O95264 CHEMBL300725 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand O95264 CHEMBL6437 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor O95264 CHEMBL344248 Binding affinity towards 5-hydroxytryptamine 3 receptor O95264 CHEMBL358412 Binding affinity towards 5-hydroxytryptamine 3 receptor O95264 CHEMBL905 Biinding activity against 5-hydroxytryptamine 1A receptor from human brain cortex using [3H]8-OH-DPAT-HT as radioligand. Q8WXA8 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL143489 Binding affinity towards 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL54125 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand Q8WXA8 CHEMBL342833 Binding affinity towards 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL140856 Binding affinity towards 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL314107 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL300725 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand Q8WXA8 CHEMBL6437 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL344248 Binding affinity towards 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL358412 Binding affinity towards 5-hydroxytryptamine 3 receptor Q8WXA8 CHEMBL905 Biinding activity against 5-hydroxytryptamine 1A receptor from human brain cortex using [3H]8-OH-DPAT-HT as radioligand. Q70Z44 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL143489 Binding affinity towards 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL54125 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand Q70Z44 CHEMBL342833 Binding affinity towards 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL140856 Binding affinity towards 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL314107 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL300725 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand Q70Z44 CHEMBL6437 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL344248 Binding affinity towards 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL358412 Binding affinity towards 5-hydroxytryptamine 3 receptor Q70Z44 CHEMBL905 Biinding activity against 5-hydroxytryptamine 1A receptor from human brain cortex using [3H]8-OH-DPAT-HT as radioligand. A5X5Y0 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL143489 Binding affinity towards 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL54125 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand A5X5Y0 CHEMBL342833 Binding affinity towards 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL140856 Binding affinity towards 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL314107 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL300725 Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand A5X5Y0 CHEMBL6437 Binding affinity for human cloned 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL344248 Binding affinity towards 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL358412 Binding affinity towards 5-hydroxytryptamine 3 receptor A5X5Y0 CHEMBL905 Biinding activity against 5-hydroxytryptamine 1A receptor from human brain cortex using [3H]8-OH-DPAT-HT as radioligand. Q13639 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). Q13639 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC Q13639 CHEMBL15228 Inhibition of ADP by the compound in response of SEC Q13639 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC Q13639 CHEMBL155917 5-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum Q13639 CHEMBL356546 Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP Q13639 CHEMBL15228 Inhibition of U-46,619 + phentolamine by the compound in response of SEC Q13639 CHEMBL1748 Displacement of [3H]GR-113808 from human recombinant 5-HT4 receptor Q13639 CHEMBL369037 Inhibitory activity against 5-hydroxytryptamine 4 receptor of guinea pig striatum using [3H]GR-113808 as radioligand Q13639 CHEMBL287045 5-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum Q13639 CHEMBL172314 Inhibitory activity against 5-hydroxytryptamine 4 receptor of guinea pig striatum using [3H]GR-113808 as radioligand P47898 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P47898 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P47898 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P47898 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P47898 CHEMBL320412 Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex P47898 CHEMBL15228 Inhibition of U-46,619 + phentolamine by the compound in response of SEC P47898 CHEMBL15228 Inhibition of Arachidonic acid by the compound in response of SEC P47898 CHEMBL14651 Stimulatory activity against serotonin secretion (SEC). P47898 CHEMBL103549 Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex P47898 CHEMBL14837 Stimulatory activity against serotonin secretion (SEC). P47898 CHEMBL128 Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex P50406 CHEMBL185958 Inhibitory concentration against human 5-hydroxytryptamine 6 receptor transfected in HeLa cells in cAMP assay P50406 CHEMBL606815 Inhibition of 5-HT stimulated cAMP production in HeLa cells expressing human 5-hydroxytryptamine 6 receptor P50406 CHEMBL193450 Inhibition of cAMP production in HeLa cells expressing human 5-HT6 receptor P50406 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P50406 CHEMBL598850 Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP formation by RIA P50406 CHEMBL598851 Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP formation by RIA P50406 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P50406 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P50406 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P50406 CHEMBL1277564 Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay P50406 CHEMBL1642877 Antagonist activity at cloned human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced cyclic AMP formation P34969 CHEMBL14508 Stimulatory activity against serotonin secretion (SEC). P34969 CHEMBL261291 Inhibition of 5HT7 receptor by radioligand binding assay P34969 CHEMBL261653 Inhibition of 5HT7 receptor by radioligand binding assay P34969 CHEMBL411104 Inhibition of 5HT7 receptor by radioligand binding assay P34969 CHEMBL493625 Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane P34969 CHEMBL15228 Inhibition of U-46,619 by the compound in response of SEC P34969 CHEMBL15228 Inhibition of ADP by the compound in response of SEC P34969 CHEMBL15228 Inhibition of AA+phentolamine by the compound in response of SEC P34969 CHEMBL81485 Binding affinity for human cloned 5-hydroxytryptamine 7 receptor P34969 CHEMBL259626 Displacement of [3H]LSD from human recombinant 5HT7 receptor P34969 CHEMBL511312 Displacement of [3H]LSD form human recombinant 5HT7 receptor P08913 CHEMBL194173 Inhibitory activity against constitutively activated human Alpha-2A adrenergic receptor transiently expressed in COS-1 cells using [3H]MK-912 P08913 CHEMBL81485 Binding affinity for human cloned Alpha-2A adrenergic receptor P08913 CHEMBL493 Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) P08913 CHEMBL1909072 Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) P08913 CHEMBL314107 Binding affinity for human cloned Alpha-2A adrenergic receptor P08913 CHEMBL331077 Binding affinity against Alpha-2A adrenergic receptor P08913 CHEMBL162370 Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement. P08913 CHEMBL313189 Binding affinity for human cloned Alpha-2A adrenergic receptor P08913 CHEMBL541105 Compound was tested for Adrenergic activity against Alpha-2 adrenergic receptor from rat aorta P08913 CHEMBL367355 Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells P08913 CHEMBL162826 Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement. P18089 CHEMBL165796 Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement. P18089 CHEMBL493 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL1909072 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL541105 Compound was tested for Adrenergic activity against Alpha-2 adrenergic receptor from rat aorta P18089 CHEMBL723 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL1909065 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL629 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL554581 Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets P18089 CHEMBL15245 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL6437 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P18089 CHEMBL726 Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) P42330 CHEMBL490979 Inhibition of human 17beta HSD5 in HEK cells P42330 CHEMBL478280 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL478490 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL477677 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL514854 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL1682200 Inhibition of AKR1C3 by fluorimetric method P42330 CHEMBL1682201 Inhibition of AKR1C3 by fluorimetric method P42330 CHEMBL478491 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL477676 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL514995 Inhibition of human 17beta-HSD5 expressed in HEK293 cells assessed as enzyme-mediated transformation of [14C]-4-androstene-3,17-dione in to [14C]-testosterone after 18 hrs P42330 CHEMBL521703 Inhibition of human 17beta HSD5 in HEK cells P21397 CHEMBL497676 Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P21397 CHEMBL386941 Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P21397 CHEMBL122279 Inhibition of human monoamine oxidase (MAO A) P21397 CHEMBL1243026 Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P21397 CHEMBL1257341 Inhibition of MAOA by spectrophotometry P21397 CHEMBL1258611 Inhibition of MAOA by spectrophotometry P21397 CHEMBL123609 Inhibition of human monoamine oxidase (MAO A) P21397 CHEMBL65252 Inhibition of human monoamine oxidase A P21397 CHEMBL122239 Inhibitory potency against Monoamine oxidase A P21397 CHEMBL1945155 Inhibition of recombinant human monoamine oxidase A expressed in insect microsomes using kynuramine as substrate after 20 mins by fluorescence spectrophotometry P21397 CHEMBL1253925 Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P27338 CHEMBL119017 Inhibitory potency against Monoamine oxidase B P27338 CHEMBL17079 Inhibitory concentration against Monoamine oxidase B was measured in baboon liver. P27338 CHEMBL470221 Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells assessed as effect on H2O2 production from para-tyramine by fluorimetric method P27338 CHEMBL1254763 Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P27338 CHEMBL386941 Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P27338 CHEMBL122279 Inhibition of human monoamine oxidase (MAO B) P27338 CHEMBL127751 Inhibition of human supersomes MAOB P27338 CHEMBL17092 Inhibitory concentration against Monoamine oxidase B was measured in baboon liver. P27338 CHEMBL1235738 Inhibitory concentration towards in human monoamine oxidase B was measured P27338 CHEMBL1243026 Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P27338 CHEMBL1253925 Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay P43405 CHEMBL485731 Inhibition of SYK-mediated FCepsilonRI signaling activity by mast cell degranulation assay P43405 CHEMBL515757 Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assay P43405 CHEMBL1834756 Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assay P43405 CHEMBL1835057 Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assay P43405 CHEMBL1835065 Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assay P43405 CHEMBL1835069 Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assay P43405 CHEMBL104279 Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis P43405 CHEMBL105427 Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis P43405 CHEMBL106095 Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis P43405 CHEMBL162 Inhibition of human Syk expressed in Sf9 cells P43405 CHEMBL33466 Inhibition of recombinant Syk Q12879 CHEMBL42146 Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor Q12879 CHEMBL41691 Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor Q12879 CHEMBL124873 Inhibition of [3H]Ro-256981 binding to N-methyl-D-aspartate glutamate receptor Q12879 CHEMBL1791461 The compound was tested for the inhibitory activity against N-methyl-D-aspartate glutamate receptor from mid-frontal region of human brain by measuring spermine-enhanced [3H]- MK-801 binding Q12879 CHEMBL42248 Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor Q12879 CHEMBL126929 Inhibition of [3H]Ro-256981 binding to N-methyl-D-aspartate glutamate receptor Q12879 CHEMBL40652 Inhibition of [3H]DCKA binding to N-methyl-D-aspartate glutamate receptor Q12879 CHEMBL182951 Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor Q12879 CHEMBL305195 Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor Q12879 CHEMBL12256 In vitro inhibitory activity at 1 uM concentration against N-methyl-D-aspartate glutamate receptor, using [3H]CGP-39653 binding assay Q12879 CHEMBL197467 Mean inhibitory concentration against [3H]ifenprodil binding to porcine N-methyl-D-aspartate (NMDA) glutamate receptor; n=3 P51575 CHEMBL1160366 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL1160359 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL1160357 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL1160356 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL334966 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL336292 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL1160365 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL599760 Antagonist activity at P2X1 receptor P51575 CHEMBL1160360 Platelet P2T receptor anatagonist activity in human platelet assay P51575 CHEMBL605325 Antagonist activity at P2X1 receptor P51575 CHEMBL1160361 Platelet P2T receptor anatagonist activity in human platelet assay Q01064 CHEMBL39285 Inhibition of calmodulin-dependent PDE(3',5'-phosphodiesterase) Q01064 CHEMBL43232 Inhibition of calmodulin-dependent PDE(3',5'-phosphodiesterase) Q01064 CHEMBL180994 Inhibition of phosphodiesterase 1 Q01064 CHEMBL181916 Inhibition of phosphodiesterase 1 Q01064 CHEMBL367927 In vitro inhibition of phosphodiesterase (PDE I). Q01064 CHEMBL361582 Inhibition of phosphodiesterase 1 Q01064 CHEMBL369081 Inhibition of phosphodiesterase 1 Q01064 CHEMBL183150 Inhibition of phosphodiesterase 1 Q01064 CHEMBL434135 Inhibition of phosphodiesterase 1 Q01064 CHEMBL362512 Inhibitory concentration against Phosphodiesterase type 1 Q01064 CHEMBL179849 Inhibition of phosphodiesterase 1 P18405 CHEMBL24958 Inhibitory concentration was tested on human 5-alpha reductase 1 isozyme P18405 CHEMBL285439 Inhibitory concentration was tested on human 5-alpha reductase 1 isozyme P18405 CHEMBL29166 In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells. P18405 CHEMBL116493 Log of inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]testosterone. P18405 CHEMBL109170 Inhibition of recombinant human Steroid 5-alpha-reductase type I P18405 CHEMBL108305 Inhibition of recombinant human Steroid 5-alpha-reductase type I P18405 CHEMBL16533 In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cells P18405 CHEMBL17194 In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cells P18405 CHEMBL116830 Log of inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]testosterone. P18405 CHEMBL312466 Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line) P18405 CHEMBL109088 Inhibition of recombinant human Steroid 5-alpha-reductase type I P31645 CHEMBL109517 In vitro ability of compound to inhibit 5-HT re-uptake of radiolabeled [3H]-tritium transmitter into synaptosome P31645 CHEMBL375889 Displacement of [3H]paroxetine from 5HTT P31645 CHEMBL563495 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL563495 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL1175 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL549965 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL551443 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL564631 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL563987 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL562108 Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells P31645 CHEMBL479409 Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells P17752 CHEMBL469463 Inhibition of TPH1 P17752 CHEMBL565307 Inhibition of human recombinant TPH1 by continuous fluorescence assay P17752 CHEMBL479924 Inhibition of TPH1 P17752 CHEMBL470083 Inhibition of TPH1 P17752 CHEMBL569291 Inhibition of human recombinant TPH1 by continuous fluorescence assay P17752 CHEMBL572143 Inhibition of human recombinant TPH1 by continuous fluorescence assay P17752 CHEMBL569517 Inhibition of human recombinant TPH1 by continuous fluorescence assay P17752 CHEMBL469480 Inhibition of TPH1 P17752 CHEMBL518324 Inhibition of TPH1 P17752 CHEMBL567452 Inhibition of human recombinant TPH1 by continuous fluorescence assay P17752 CHEMBL469462 Inhibition of TPH1